Lipid metabolism changes in patients with severe COVID-19

We investigated the dynamic changes in lipid profiles and their correlations with disease severity clinical outcome patients severe COVID-19. retrospectively reviewed 519 COVID-19 confirmed outcomes (discharged or deceased), admitted to West Court of Union Hospital Wuhan, China, between 29 January 8 April 2020. Altogether, 424 patients, including 34 non-survivors 390 survivors, were included final analyses. During hospitalization, low-density lipoprotein cholesterol (LDL-C), total (TC), high-density (HDL-C) apolipoprotein A-I (apoA-I) showed an increasing trend but a downward non-survivors. The serum concentrations HDL-C apoA-I inversely correlated C-reactive protein (CRP), length hospital stay scores. For in-hospital deaths, areas under receiver operating characteristic curves (AUCs) ratios CRP/HDL-C CRP/apoA-I at admission 0.84 0.83, respectively. Moreover, high (＞77.39) (＞72.37) had higher mortality rates during hospitalization (log-rank p < 0.001). Logistic regression analysis demonstrated that hypertension, lactate dehydrogenase, SOFA score, High ratio independent predictors mortality. COVID-19, are dramatically decreased is significantly associated increase poor prognosis.